Adrenergic β-Receptor Blocking Activity of (3-Amino-2-hydroxy) propoxy-3, 4-dihydrocarbestyril Derivatives in Anesthetized Dog
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چکیده
منابع مشابه
Design, synthesis and activity study of aminopeptidase N targeted 3-amino-2-hydroxy-4-phenyl-butanoic acid derivatives.
A series of (2RS,3S)-3-amino-2-hydroxy-4-phenyl-butanoic acids (AHPA) derivatives (MA0-MA7) were synthesized. The in vitro aminopeptidase N (APN) enzyme and cell proliferation assay of target compounds were investigated. The results showed that most compounds displayed potent inhibitory activities against APN, compound MA0 showed even better inhibitory effects than bestatin on both enzyme activ...
متن کاملPREPARATION OF 2S,3S-N-ISOBUTYL-N-(2- HYDROXY-3-AMINO-4-PHENYLBUTYL)-P- NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-l,3- DIAMINES
The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2hydroxy -3 -amino -4-phenylbu tyl) -pnitrobenzenesulfonylamide...
متن کاملPREPARATION OF 2S,3S-N-ISOBUTYL-N-(2- HYDROXY-3-AMINO-4-PHENYLBUTYL) -P- NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-l,3- DIAMINES
Inventors: Aslam A. Malik, Cameron Park, CA (US); Hasan Palandoken, Woodland, CA (US); Joy A. Stringer, Carmichael, CA (US); Roland P. Carlson, Folsom, CA (US); John Leach, Gold River, CA (US); Thomas G. Archibald, Fair Oaks, CA (US); Robert G. Miotke, Gold River, CA (US) PREPARATION OF 2S,3S-N-ISOBUTYL-N-(2HYDROXY-3-AMINO-4-PHENYLBUTYL) -PNITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIV...
متن کاملSynthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates
A series of twenty substituted 2-hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates were prepared and characterized. As similar compounds have been described as potential antimycobacterials, primary in vitro screening of the synthesized carbamates was also performed against two mycobacterial species. 2-Hydroxy-3-[2-(2,6-dimethoxyphenoxy)ethylamino]-propyl 4-(butoxycarbon...
متن کاملSynthesis and in vitro Antibacterial Activity of Some Novel 2-Amino-4, 6-D Derivatives
Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. Keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. Eight novel 2-amino-4,6-diarylpyrimidine derivatives ...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1974
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.94.5_613